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James R Rusche Selected Research

anthranilamide

1/2015Mechanism of Action of 2-Aminobenzamide HDAC Inhibitors in Reversing Gene Silencing in Friedreich's Ataxia.
9/2012Rationale for the development of 2-aminobenzamide histone deacetylase inhibitors as therapeutics for Friedreich ataxia.

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James R Rusche Research Topics

Disease

11Friedreich Ataxia (Friedreich's Ataxia)
01/2015 - 09/2009
8Neurodegenerative Diseases (Neurodegenerative Disease)
10/2014 - 09/2009
4Huntington Disease (Huntington's Disease)
01/2016 - 09/2009
2Epilepsy (Aura)
07/2008 - 07/2006
2Seizures (Absence Seizure)
08/2006 - 07/2006
1Hematologic Neoplasms (Hematological Malignancy)
11/2015
1Leukemia
11/2015
1Lymphoma (Lymphomas)
11/2015
1Neoplasms (Cancer)
11/2015
1Spinal Muscular Atrophy (Progressive Muscular Atrophy)
10/2013
1Genomic Instability
08/2013
1Parkinson Disease (Parkinson's Disease)
02/2013
1Dyskinesias (Dyskinesia)
02/2013
1Ataxia (Dyssynergia)
01/2010
1Bipolar Disorder (Manic Depressive Psychosis)
06/2008
1Status Epilepticus (Complex Partial Status Epilepticus)
07/2006
1Autistic Disorder (Autism)
09/2002

Drug/Important Bio-Agent (IBA)

12Histone Deacetylase InhibitorsIBA
11/2015 - 09/2009
8FrataxinIBA
01/2015 - 01/2010
6Histone Deacetylases (Histone Deacetylase)IBA
01/2016 - 09/2009
3Mitochondrial Proteins (Mitochondrial Protein)IBA
01/2015 - 12/2011
3Proteins (Proteins, Gene)FDA Link
10/2013 - 01/2010
3UridineIBA
07/2008 - 07/2006
2histone deacetylase 3IBA
01/2016 - 09/2009
2anthranilamideIBA
01/2015 - 09/2012
2Biomarkers (Surrogate Marker)IBA
10/2014 - 11/2011
2HeterochromatinIBA
09/2012 - 06/2011
2SecretinFDA Link
08/2006 - 09/2002
2Anticonvulsants (Antiepileptic Drugs)IBA
08/2006 - 07/2006
1EnzymesIBA
01/2016
1Histones (Histone)IBA
01/2016
1Histone Acetyltransferases (Histone Acetyltransferase)IBA
01/2016
1RGFP966IBA
11/2015
1PanobinostatIBA
11/2015
1CaspasesIBA
11/2015
1VorinostatFDA Link
11/2015
1belinostatIBA
11/2015
1romidepsin (FK228)FDA Link
11/2015
1ChromatinIBA
08/2013
1N- (6- (2- aminophenylamino)- 6- oxohexyl)- 4- methylbenzamideIBA
02/2013
1Levodopa (L Dopa)FDA LinkGeneric
02/2013
1Dopamine (Intropin)FDA LinkGeneric
02/2013
11- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
02/2013
1Messenger RNA (mRNA)IBA
09/2012
1polyglutamineIBA
05/2012
1uridine triacetateIBA
06/2008
1Phosphorus (Red Phosphorus)IBA
06/2008
1Neuroprotective AgentsIBA
07/2006
1Pilocarpine (Ocusert)FDA LinkGeneric
07/2006
1LithiumIBA
07/2006
1Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))IBA
09/2002
1Therapeutic UsesIBA
09/2002
1Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA
09/2002
1Glucagon (Glukagon)FDA Link
09/2002
1Peptides (Polypeptides)IBA
09/2002

Therapy/Procedure

6Therapeutics
10/2014 - 09/2009